Colon cancer under 50, gut health, and the microbiome lead this solo episode of the Beautifully Broken Podcast, where Freddie Kimmel breaks down five things that go up your butt for better health, and three that shouldn’t. Colorectal cancer is now the leading cause of cancer death in adults under 50, and half of those diagnoses are in people 45 to 49.

Freddie gets personal about his own objectively bad gut test, then walks through screening, butyrate, fecal microbiota transplant, rectal ozone, and pelvic floor and prostate therapy, with the studies behind each and an honest look at where the evidence stops. Long story long: find a guide, get screened, and test your poop.

In this episode

Cologuard vs. colonoscopy, and why screening at 45 matters
The 2013 NEJM trial where FMT resolved recurrent C. diff in 15 of 16 patients
How rectal ozone signals through Nrf2 and NF-kB, and where the FDA stands
Stanford’s pelvic floor trigger point protocol for chronic prostatitis

For education only, not medical advice. Rectal therapies, FMT and ozone carry real risks. Work with a licensed clinician, and never skip recommended cancer screening.

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Episode highlights

00:00 Why we're talking about butt stuff 02:04 My gut test came back objectively bad 03:22 #1 Wipe or scope: colon cancer under 50 04:29 38 trillion bacteria, 30 trillion you 06:24 Antibiotics, glyphosate, low fiber, chronic stress 08:26 Colibactin and the Nature 2025 study 09:08 Cologuard vs. colonoscopy 11:23 What hospitals don't test + the Bristol stool chart 12:40 #2 Butyrate enemas and the 1992 colitis study 15:59 #3 FMT: the poop transplant 17:38 The 2013 NEJM C. diff trial 19:37 Bile acids, Rebyota and Vowst 20:37 Why the donor is everything 23:36 #4 Rectal ozone 26:22 Nrf2, NF-kB and oxidative "leg day" 29:25 #5 Pelvic floor and prostate massage 31:31 Chronic prostatitis and the UPOINT framework 33:15 Stanford's trigger point protocol 35:57 Didn't make the list: butthole sunning 37:00 Coffee enemas: against my own bias 38:46 Red light (no orifice needed) 40:34 My Tiny Health results and protocol 44:16 Shotgun metagenomics vs. GI-MAP, 16S and Viome 46:41 Find a clinician, don't skip screening

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