We're bringing this powerhouse episode back to your ears—because it’s just that good. Microbiologist and gut health innovator Dr. Kiran Krishnan returns for what might be our most impactful conversation yet. Together, we explore why your gut microbiome is the ultimate predictor of resilience, longevity, and even how well you’ll respond to illness.

Kiran breaks down the staggering impact of microbial diversity, how modern life has wiped out essential strains, and why his team is resurrecting ancient microbes for the modern gut. We also get into what he actually takes when flying 400,000 miles a year, the truth about keto, and how poop (yep!) holds the key to personalized healing.

It’s science, inspiration, and a whole lot of fun—complete with a poop-testing parody of “Dick in a Box.” You’ll walk away with five daily practices to boost gut diversity and a renewed belief in your body’s natural brilliance.

CONNECT WITH DR. KIRAN KRISHNAN + MICROBIOME LABS

Website: microbiomelabs.com
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Episode highlights

03:42 How the digital world is changing what we know and how we connect 06:10 Building resilience vs. chasing perfection in health 08:24 What centenarians around the world teach us about gut diversity 13:01 Why your poop holds the answers: shape, frequency, and clues to dysfunction 16:28 Microbial extinction and why we’ve lost two-thirds of our gut species 21:56 What is MegaGenesis and how keystone strains are being brought back 23:54 Why restrictive diets harm the gut—and what to do instead 28:49 The new FXBiome test: better resolution, actionable insights 38:24 Covid, long-haul illness, and the gut’s predictive power 43:57 5 lifestyle upgrades for gut diversity: from fasting to forest walks 49:32 Why your household shares microbes—and why dogs help 58:07 Kiran’s closing message: there’s always hope when you start with the gut

Read the full transcript

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Microbiome Lab

The three fundamental aspects of gut health include: the microbial population, physical structures, and regulatory immune function. Ahealthy gut microbiome is multi-faceted and relies heavily upon all 3 of these factors, like a three-legged stool.